1P004 Separation of amyloid fibrillation site from active site in calcitoni

PROBING THE ACTIVE SITE OF RHODANESE WITH DISULFIDE REAGENTS

Discovery of active site of vinblastine as application of nanotechnology in medicine

Objective(s): Vinblastine is antimitotic, anticancer medicine that disturbs normal microtubule formation and favours depolymerisation. Structural study and finding the active site of vinblastine are the targets of this research.   Materials and Methods: Vinblastine was optimized in vacuum and then in different solvents by Density Functional Theory (DFT) method. Nuclear Magnetic Resonance (NMR) ...

Active site nature of magnesium dichloride-supported titanocene catalysts in olefin polymerization

Heterogeneous Ziegler-Natta and homogeneous metallocene catalysts exhibit greatly different active sitenature in olefin polymerization. In our previous study, it was reported that MgCl2-supported titanocenecatalysts can generate both Ziegler-Natta-type and metallocene-type active sites according to the type of activators.The dual active site nature of the supported titanocene catalysts was furt...

Faunal Remains from Shikarpur, a Harappan Site in Gujarat, India

This paper deals with the preliminary observations of the analysis conducted on the faunal remains unearthed at thesite of Shikarpur. A single trench ES4 was selected as a research sample from the excavation conducted by theDepartment of Archaeology and Ancient History; M.S. University of Baroda, Gujarat State, India in 2007-08. Atotal of 6250 skeletal fragments were analysed of which only 3219...

Site-directed mutational analysis of active site residues in the acetate kinase from Methanosarcina thermophila.

Acetate kinase catalyzes the magnesium-dependent transfer of the gamma-phosphate of ATP to acetate. The recently determined crystal structure of the Methanosarcina thermophila enzyme identifies it as a member of the sugar kinase/Hsc70/actin superfamily based on the fold and the presence of five putative nucleotide and metal binding motifs that characterize the superfamily. Residues from four of...